Medicinal Chemistry and Drug Discovery & Development 2019 (MCADDI 2019) BIOCON ACADEMY, Bangalore, India
Monday, March 4th 2019
11:00-18:00 REGISTRATION  
12:00-12:45 LUNCH  
Session Chair Balu Balasubramanian  
12:50-13:00 WELCOME Dr. Balu Balasubramanian Pharma Innovaon Sourcing Center, USA
13:00-15:00

Lectures 1 and 2

Basic Principles of Medicinal Chemistry

Prof. Thomas Prisinzano, Univ. of Kansas, USA
15:30-16:30 Lecture 3
Target Idenficaon and Validaon
Dr. Manjunath Ramarao Biocon-BMS R&D Center, India
16:45-17:15 TEA BREAK  
Session Chair William Greenlee  
17:15-18:15 Lecture 4
Hit Idenficaon: High-Throughput / Phenotypic/ Virtual / Fragment screenin
Dr. Nagaraj Gowda
18:30-19:30 Lecture 5
Hit-to-Lead Process
Dr. Manjunath Ramarao Biocon-BMS R&D Center, India
19:45-20:30 RECEPTION AND DINNER  
Tuesday, March 5th, 2019
Session Chair Thomas Prisinzano  
8:30-9:30 Lecture 6
Lead Opmizaon
Dr. Bruce Ellsworth Bristol-Myers Squibb, USA
9:45-10:45 Lecture 7
Designing Around Toxicophores in Drug Discovery
Dr. Nick Meanwell Bristol-Myers Squibb, USA
11:00 -11:30 TEA BREAK  
11:30- 12:30 Lecture 8
Special Topic: Applicaons of Fluorine in Drug Design and Discovery
Dr. Nick Meanwell Bristol-Myers Squibb, USA
12:45-13:45 LUNCH BREAK  
Session Chair Thomas Prisinzano  
13:45-14:45 Lecture 9
Enzymes, Receptors and Ion Channels
Dr. Manjunath Ramarao Biocon-BMS R&D Center, India
15:00-16:00 Lecture 10
G-Protein Coupled Receptors
Dr. Bruce Ellsworth Bristol-Myers Squibb, USA
16:15-16:45 TEA BREAK  
16:45-17:45 Lecture 11
Taccal Applicaons of Bioisosteres in Drug Design
Dr. Nick Meanwell Bristol-Myers Squibb, USA
18:00-19:00 Lecture 12
Applicaons of Heterocycles in Drug Design
Dr. Nick Meanwell Bristol-Myers Squibb, USA
Wednesday, March 6th, 2019
Session Chair: William Greenlee  
8:30-9:30 Lecture 13
Lessons in Structure-Based Drug Design
Dr. Vincent Stoll AbbVie, USA
9:45-10:45 Lecture 14
Principles of Molecular Interacons
Dr. Vincent Stoll AbbVie, USA
11:00-11:30 TEA BREAK  
11:30-12:30 Lecture 15
Protein Binding
Dr. Swamy Yeleswaram Incyte, USA
12:45-13:45 LUNCH BREAK  
Session Chair: Vincent Stoll  
13:45-14:45 Lecture 16
Drug Metabolism and PK
Dr. Swamy Yeleswaram Incyte, USA
15:00-16:00 TEA BREAK/Exhibion Hall  
16:00-17:30 Lecture 17
Case History Saroglitazar (Lipaglyn®) for Treatment of Dyslipidemia and Hypertriglyceridemia in Type II
Dr. Mukul JainZydus, India
Thursday, March 7th, 2019
Session Chair: Mukul Jain  
8:30-9:30 Lecture 18
Case History: Ruxolinib (Jakafi®) for Treatment of Polycythemia Vera and Myelofibrosis
Dr. Swamy Yeleswaram Incyte, USA
9:45-10:45 Lecture 19
Case History: Pharmaceucal Development aspects of Ruxolinib (Jakafi®)
Dr. Swamy Yeleswaram Incyte, USA
11:00-11:30 TEA BREAK  
11:30-12:30 Lecture 20
Introducon to Biologics Biologics and Biosimilar Design and Development - Part 1
Dr. Narendra Chirmule Biocon, India
12:45-13:45 LUNCH BREAK  
Session Chair: Swamy Yeleswaram  
13:45-14:45 Lecture 21
Introducon to Biologics Biologics and Biosimilar Design and Development - Part 2
Dr. Narendra Chirmule Biocon, India
15:00-16:00 Lecture 22
Anbody-Drug Conjugates (ADCs)
Dr. Nin Damle Sun Pharma, India
16:15-17:00 TEA BREAK/Exhibion Hall  
Friday, March 8th, 2019
Session Chair: Sudhir Kumar Singh -GVK Biosciences, India  
8:30-9:30 Lecture 23
General Introducon to Process Chemistry; Phase-appropriate Process Development
Dr. Vaidyanathan Rajappa Biocon-BMS R&D Center, India
9:45-10:45 Lecture 24
Drug Product Development - Basic Principles (Pharmaceucs & Analycal)
Dr. Sridhar Desikan Dr. Reddy's Laboratories, India
11:00 – 11:30 TEA BREAK  
11:30-12:30 Lecture 25
Case History of Integrated Drug Discovery and Process Development: Part 1 HIV-1 Aachment Inhibitors
Dr. Nick Meanwell Bristol-Myers Squibb, USA
12:30-13:30 LUNCH BREAK  
Session Chair: Pravin Iyer - Glenmark Pharma, India  
13:30-14:30 Lecture 26
Case History of Integrated Drug Discovery and Process Development: Part 2 HIV-1 Aachment Inhibitors
Dr. Marn Eastgate Bristol-Myers Squibb, USA
14:45-15:45 Lecture 27
Bio Pharmaceucs – Case History HIV Aachment Inhibitors and Others
Dr. Manisha Desai Bristol-Myers Squibb, USA
17:00 Recepon, Key Note Lectures
Venue: Hotel Radha Regent, Electronic City
 
Session Chairs: Bindu Ajit, Manjunath Rama Rao, Vaidyanathan Rajappa  
17:30-18:00 Keynote Lecture-1 Current Trends in Indian Pharmaceucal and Biotechnology Ms. Kiran Mazumdar Shaw Biocon, India
18:00-18:30 Keynote Lecture-2
Future Trends in Drug Discovery
Dr. Litao Zhang
18:30-19:00 Keynote Lecture-3
Perspecves on Pharmaceucal Development
Dr. Nancy Barbour
19:00 -22:00 RECEPTION AND DINNER  
Saturday, March 9th, 2019
Session Chair: Venkata Palle, Lupin, India  
8:30-9:30 Lecture 28
Integrated Case History - Process Development
Dr. Vaidyanathan Rajappa Biocon-BMS R&D Center, India
9:45-10:45 Lecture 29
Case History of Integrated Drug Discovery and Process Development: Beta Secretase: Past Present and Future Part 1
Dr. Jennifer Allen Amgen- USA
11:00-12:00 Lecture 30
Case History of Integrated Drug Discovery and Process Development: Beta Secretase: Past Present and Future Part 2
Dr. Jason Tedrow Amgen- USA
12:15PM -12:30 Concluding Remarks Dr. William Greenlee
12:30-1:30 PM LUNCH  
End of Course